> How can I interpret the results?
- A negative test means that Colox did not detect any abnormality of markers associated to colorectal cancer and adenomas. The negative predictive value of the test is 99.9%. Periodic testing for colorectal cancer is recommended for the patient.
- A positive test does not necessarily mean that the patient has cancer. This means that Colox has detected variation in biomarkers associated to colorectal cancer or adenomatous polyps. The patient has adenomatous polyps with a probability of 52% (Positive predictive value) but only 2% of positive tests will be cancer. A positive result requires a follow-up diagnostic colonoscopy.
> What if a patient has symptoms while the test is negative?
Colox is an early detection test for colorectal cancer and colorectal lesions (adenomatous polyps). In case of symptoms, follow the medical guidelines recommended by the Swiss Society of Gastroenterology and the League Against Cancer Switzerland, which say to perform a colonoscopy. We remind you that a colonoscopy is the reference exam for people who have symptoms.
> How to explain a normal colonoscopy to a patient who has received a positive test?
The presence of a false-positive must not intervene in patient care and especially not in the suspicion of other gastrointestinal pathologies or presence of other adenocarcinomas. The fact that colonoscopy is negative is very reassuring because nowadays the rate of colorectal lesions missed at this examination is very low. Patients with a negative colonoscopy and a positive Colox test do not require further examination, but normal clinical follow-up is indicated. In this case it is likely a false positive of the Colox test.
> After how long do I have to repeat the test?
It is recommended to get screened every two years.
> How much the test cost?
Colox costs CHF 279. Colox is not reimbursed for the moment. Some insurances may cover a part of the cost, ask your insurance directly.
